Genome Plasticity in Health and Disease


Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.

Key Features
  • Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders
  • Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Active researchers, basic and translational scientists, clinicians, postgraduates, and students in the areas of genetics, human genomics, pathology, cellular biology, organismal biology, molecular biology, biochemistry, and bioinformatics

Table of Contents
  • 1. Impact of Genome Plasticity on Health and Disease
  • Section I. Plasticity of the Human Genome
    2. Overview of the Human Genome
    3. Methods for Epigenomic Analyses: DNA Methylation
    4. Genomic Databases
    5. Genomic Variability: Germline, Somatic and de novo Variants
    6. Founder Variations in Isolated Populations
    7. DNA Methylation
    8. Chromatin, Histones and Histone Modifications in Health and Diseases
    9. Networks of Transcription Factors
    10. Centromere and Telomere Dynamics in Humans
  • Section II. Human Genome Plasticity and Diseases
    11. Genome Plasticity and Cardiovascular Diseases
    12. Genome Plasticity and Neuropsychiatric Disorders
    13. Genome Plasticity and Endocrine Diseases
    14. Implications of Genome Plasticity for Drug Development

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